Postoperative NSAIDs and COX-2 inhibitors: cardiovascular risks and benefits
نویسندگان
چکیده
منابع مشابه
Cox-2 Inhibitors and Cardiovascular Risks
The controversy over the cardiovascular risks of cox-2 inhibitors stems from 2 main trials: VIGOR and CLASS. These two trials were designed to assess the gastrointestinal safety of rofecoxib (Vioxx) and celecoxib (Celebrex), respectively. From these trials, it was observed that the cox-2 inhibitors had a higher number of cardiovascular events than the NSAIDS that they were paired against. For e...
متن کاملCOX - 2 Inhibitors , Other NSAIDs , and Cardiovascular Risk
The concept was appealing in its simplicity. Traditional nonsteroidal antiinflammatory drugs (NSAIDs) inhibited both isoforms of the enzyme cyclooxygenase responsible for the first step in the conversion of arachidonic acid into a variety of prostaglandins, thromboxanes, and leukotrienes throughout the body. The anti-inflammatory and pain-relieving effects of NSAIDs resulted from inhibition of ...
متن کاملCardiovascular and gastrointestinal effects of COX-2 inhibitors and NSAIDs: achieving a balance
Conventional 'nonselective' nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the treatment of pain and inflammation; however, the potential gastrointestinal risks associated with their use can be a cause for concern. In response to the adverse effects that can accompany nonselective NSAID use, selective cyclo-oxygenase (COX)-2 inhibitors were developed to target the COX-2 isoen...
متن کاملPractical approaches to minimizing gastrointestinal and cardiovascular safety concerns with COX-2 inhibitors and NSAIDs
Nonsteroidal anti-inflammatory drugs (NSAIDs) are highly effective in treating the pain and inflammation associated with osteoarthritis and rheumatoid arthritis, but it is well recognized that these agents are associated with substantial gastrointestinal toxicity. Treatment guidelines suggest that patients with one or more risk factors for NSAID associated ulcers should be prescribed preventive...
متن کاملRisks and benefits of COX-2 inhibitors vs non-selective NSAIDs: does their cardiovascular risk exceed their gastrointestinal benefit? A retrospective cohort study.
OBJECTIVES The risk of acute myocardial infarction (AMI) with COX-2 inhibitors may offset their gastrointestinal (GI) benefit compared with non-selective (NS) non-steroidal anti-inflammatory drugs (NSAIDs). We aimed to compare the risks of hospitalization for AMI and GI bleeding among elderly patients using COX-2 inhibitors, NS-NSAIDs and acetaminophen. METHODS We conducted a retrospective co...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2005
ISSN: 0007-0912
DOI: 10.1093/bja/aei204